Age- and sex-specific profiles of temporal fasting plasma glucose variability in a population undergoing routine health screening

Abstract Background Fasting plasma glucose (FPG) variability is a significant predictor of mortality, especially in patients with poor glycemic control. This study aimed to explore the temporal age- and sex-specific profiles FPG Chinese population undergoing routine health screening guide development targeted public interventions for prevention control diabetes. Methods In this cross-sectional study, we used general linear model compare differences values between sexes across age groups 101,886 Nanjing residents who underwent physical examination at Health Management Center, First Affiliated Hospital Medical University, 2018. The as function time, age, sex, independently combination, was analyzed. Results participants included 57,455 (56.4%) males 44,431 (43.6%) females, mean ± SD 42.8 15.0 years. average level 5.5 1.1 mmol/L. monthly variation contributed 22% overall variability. A main effect group observed (F = 7.39, P < 0.05), an excellent fitting (Eta-squared =0.15). showed sex percentage difference coefficient variation, which 34.1% higher than females. There were interaction effects month*age*sex day*age*sex. Conclusions Temporal evident affected by both sex. To avoid complications associated variability, should be directed females specific ages optimal reduce risk diabetes cardiovascular events.